Protein-Packed Butternut Squash Breakfast Casserole

Posted on December 7, 2025

By: Betty Miller

Protein-Packed Butternut Squash Breakfast Casserole served in a white dish

The morning rush can often feel like a chaotic dance, particularly when trying to get everyone fed and out the door – but it doesn’t have to end in cereal. Enter the Butternut Squash Breakfast Casserole with Sausage, an all-in-one dish that packs a protein punch of around 20 grams per serving! Imagine the warm, savory aroma wafting through your kitchen, a perfect blend of seasoned sausage and sweet butternut squash that could make any morning brighter.

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Butternut Squash Breakfast Casserole with Sausage


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  • Author: betty-m
  • Total Time: 45 minutes
  • Yield: 4 servings 1x
  • Diet: Gluten-Free, High-Protein

Description

A delicious and nutritious breakfast casserole featuring a blend of turkey sausage, sweet butternut squash, and nutrient-packed spinach, perfect for busy mornings.


Ingredients

Scale
  • 1/2 lb. lean ground turkey sausage
  • 2 tsp. olive oil
  • 2 cups butternut squash, peeled and diced
  • 1/2 red onion, diced
  • 1/2 tsp. salt
  • 1/2 tsp. garlic powder
  • 1/2 tsp. oregano
  • 1/2 tsp. pepper
  • 4 cups spinach, chopped
  • 4 eggs
  • 4 egg whites

Instructions

  1. Preheat the oven to 400 degrees.
  2. Heat a skillet over medium-high heat. Add the sausage and cook until no longer pink, breaking it up as it cooks.
  3. Remove sausage and set aside. In the same pan, add olive oil, then the butternut squash and red onion.
  4. Cook for 8-10 minutes until tender, adding 1-2 tablespoons of water if burning.
  5. Add salt, garlic powder, oregano, and pepper, stirring to distribute the flavors.
  6. Add spinach and cook until wilted, about 1-2 minutes.
  7. Whisk together eggs until frothy. In a baking dish sprayed with cooking spray, combine sausage and butternut squash mixture.
  8. Pour the eggs over the top, ensuring everything is coated.
  9. Bake for 25-30 minutes until eggs are set; a toothpick should come out clean when done.

Notes

For a crispier top, broil the casserole for the last 1-2 minutes. Assemble and refrigerate overnight for stress-free mornings. Make sure to pre-cook the veggies well to avoid a soggy bottom.

  • Prep Time: 15 minutes
  • Cook Time: 30 minutes
  • Category: Breakfast
  • Method: Baking
  • Cuisine: American

Nutrition

  • Serving Size: 1 slice
  • Calories: 280
  • Sugar: 5g
  • Sodium: 400mg
  • Fat: 12g
  • Saturated Fat: 4g
  • Unsaturated Fat: 6g
  • Trans Fat: 0g
  • Carbohydrates: 22g
  • Fiber: 5g
  • Protein: 20g
  • Cholesterol: 240mg

Why This Butternut Squash Breakfast Casserole is a Winner

With the hustle and bustle of everyday life, it’s crucial to have a go-to breakfast that’s not only delicious but also nourishing. This casserole checks all those boxes. It’s a delightful mix of flavors with the familiar warmth of sausage and the subtle sweetness of butternut squash. Plus, it’s a breeze to prepare. Whip it up the night before, pop it in the oven, and you’ll have a satisfying breakfast ready to greet your family every busy morning!

Ingredient Breakdown

To craft this delicious breakfast casserole, here’s what you’ll need:

  • 1/2 lb. lean ground turkey sausage: A healthier option that still delivers on flavor.
  • 2 tsp. olive oil: For sautéing and a hint of richness.
  • 2 cups butternut squash, peeled and diced: The star of the dish providing sweetness and nutrition.
  • 1/2 red onion, diced: Adds a mild onion flavor that enhances the entire dish.
  • 1/2 tsp. salt: To season evenly.
  • 1/2 tsp. garlic powder: A must for that aromatic flavor.
  • 1/2 tsp. oregano: Perfect for a hint of Mediterranean flair.
  • 1/2 tsp. pepper: To spice things up.
  • 4 cups spinach, chopped: Nutrient-packed and a great way to sneak in some veggies.
  • 4 eggs, plus 4 egg whites (or more eggs): The binding magic that brings everything together.

Step-by-Step Method

Ready to create your glorious casserole? Let’s get cooking!

  1. Preheat the oven to 400 degrees.
  2. Heat a skillet over medium-high heat.
  3. Add the sausage and cook until no longer pink, breaking it up as it cooks. Remove and set aside. Keep it moving to ensure even browning.
  4. Add the olive oil to the pan. Once hot, add the butternut squash and red onion.
  5. Cook for 8-10 minutes until squash and onion are tender, adding 1-2 tablespoons of water if burning. A splash of water will help steam the veggies.
  6. Add the salt, garlic powder, oregano, and pepper. Stir together to distribute the flavors evenly.
  7. Add the spinach and cook until it wilts, about 1-2 minutes. It’s a great way to add greens without overwhelming the dish.
  8. Whisk together the eggs until frothy for a light and airy texture.
  9. Add the sausage and butternut squash mixture to a baking dish sprayed with cooking spray.
  10. Pour the eggs over the top, ensuring everything is coated.
  11. Bake for 25-30 minutes until the eggs set and are cooked through. A toothpick should come out clean when it’s done.

Nutrition Breakdown

Each serving of this breakfast casserole does wonders for your health with approximately:

  • Serving Size: 1 slice
  • Calories: 280
  • Protein: 20 grams
  • Carbohydrates: 22 grams
  • Fat: 12 grams
  • Fiber: 5 grams

Packed with goodness, this recipe brings a wholesome start to your day, and the fiber from the spinach and squash keeps you full longer, making it an excellent choice for busy mornings.

How to Serve It Best

This casserole is the ideal cozy breakfast treat. Slice it into generous squares and serve warm, perhaps with a dollop of Greek yogurt or a drizzle of hot sauce if you’re feeling adventurous! Pair it with fresh fruit or a side of crispy turkey bacon for a balanced breakfast that will keep your stomach satisfied until lunch.

How to Store It Right

To keep your casserole fresh, store any leftovers in an airtight container in the fridge for up to 4 days, or freeze for up to 3 months. When you’re ready to enjoy, simply reheat in the oven at 350 degrees until warmed through (about 15-20 minutes). For a freshness tip, add a sprinkle of fresh herbs after reheating to brighten the flavor!

Pro Tips

  • Texture Boost: For a crispier top, broil the casserole for the last 1-2 minutes of baking – just keep an eye on it!
  • Prep Ahead: Assemble and refrigerate overnight for a stress-free morning.
  • Even Cooking: Make sure to dice the butternut squash uniformly for even cooking.
  • Egg-Wise: If you’re short on time, you can use 8 whole eggs instead of the 4 eggs and 4 egg whites.
  • Flavor Check: Taste the sausage before cooking to ensure it’s well-seasoned, adjusting spices if necessary.

Flavor Experiments

Feel free to switch things up!

  • Seasonal Twist: In fall, add chopped apples for a sweet crunch.
  • Gourmet Spin: Use feta or goat cheese sprinkled on top before baking for a creamy contrast.
  • Playful Mix: Add some diced bell peppers or jalapeños for a spicy kick!

Learn from My Mistakes

Here are some common pitfalls and how to avoid them:

  • Soggy Bottom: No one likes a soggy crust. Always pre-cook your veggies well.
  • Egg Overcook: If you bake too long, the eggs can turn rubbery. Set a timer for 25 minutes and check!
  • Uneven Flavor: Don’t skip seasoning; a well-seasoned base makes all the difference!
  • Too Dense: Whisk your eggs vigorously to incorporate air for a fluffier casserole.
  • Burnt Edges: Cover the casserole with foil for the first half of baking if you notice it browning too quickly.

Creative Second-Day Ideas

Leftovers? No problem! Here’s what you can do with them:

  • Scramble it Up: Toss a slice into your morning scrambled eggs for added flavor.
  • Savory Breakfast Burritos: Wrap leftover casserole in a tortilla with avocado and salsa for a portable breakfast.
  • Fresh Omelet: Chop the leftovers and use them as a filling in an omelet for a gourmet brunch experience.

Quick Questions

Can I use regular pork sausage instead of turkey? Absolutely! Pork sausage will add more fat, resulting in a richer flavor, so just adjust the seasoning accordingly.

How do I make this gluten-free? All ingredients are gluten-free as listed, but always double-check your spices for hidden gluten.

Can I freeze this casserole? Yes! It freezes wonderfully. Just wrap individual portions tightly in plastic wrap and foil for the best results.

What can I use in place of spinach? Chopped kale or Swiss chard can be great substitutes, just cook them until wilted before adding!

Embrace this Butternut Squash Breakfast Casserole with Sausage as your new breakfast hero. Not only does it tick all the boxes of convenience, nutrition, and taste, but it will also make your mornings feel just a bit more special!

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