High-Protein Ground Beef Casserole

Posted on December 25, 2025

By: Betty Miller

High-protein ground beef casserole with vegetables and cheese

When it comes to hearty family dinners, there’s nothing quite like a cozy casserole to bring everyone together. It’s a warm, inviting dish that combines the rich flavors of beef with tender pasta, creating a mouthwatering experience that delivers the protein-packed punch each plate desires. Did you know that a typical serving of this Simple Ground Beef Casserole provides an impressive 26 grams of protein? Picture the savory aromas wafting through your kitchen as this dish bakes to melty perfection—let’s make it happen!

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Simple Ground Beef Casserole


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  • Author: betty-m
  • Total Time: 40 minutes
  • Yield: 6 servings 1x
  • Diet: None

Description

A hearty and savory casserole combining beef, pasta, and cheese for the perfect family dinner.


Ingredients

Scale
  • 1 pound uncooked penne
  • 1 tablespoon olive oil
  • 1 pound lean ground beef
  • 1/2 medium onion, chopped
  • 1 clove garlic, minced
  • 1.5 cups marinara sauce
  • Salt & pepper to taste
  • 1.5 cups shredded cheddar cheese

Instructions

  1. Preheat your oven to 400°F (200°C) and move the rack to the middle position.
  2. Grease a 9×13 baking dish.
  3. Boil a large, salted pot of water for the penne. Cook the pasta for 10 minutes, slightly underdone.
  4. In a skillet, add olive oil, ground beef, and chopped onion. Sauté over medium-high heat for 10 minutes until browned.
  5. Stir in minced garlic and cook for another minute.
  6. If there’s excess fat, spoon it out, then add marinara sauce and warm for about 2 minutes. Season with salt and pepper.
  7. Drain the penne and place it in the greased baking dish. Pour the beef mixture over the pasta and toss until combined.
  8. Top with shredded cheddar cheese, adding extra cheese if desired.
  9. Bake for 10 minutes, uncovered, until cheese is melted and bubbling. Optional: broil for a couple of minutes for a crispy top.
  10. Serve immediately.

Notes

For added flavor, consider mixing in bell peppers or using a homemade sauce.

  • Prep Time: 15 minutes
  • Cook Time: 25 minutes
  • Category: Main Course
  • Method: Baking
  • Cuisine: American

Nutrition

  • Serving Size: 1 serving
  • Calories: 400
  • Sugar: 4g
  • Sodium: 600mg
  • Fat: 18g
  • Saturated Fat: 7g
  • Unsaturated Fat: 8g
  • Trans Fat: 0g
  • Carbohydrates: 35g
  • Fiber: 3g
  • Protein: 26g
  • Cholesterol: 70mg

Why This Simple Ground Beef Casserole Is a Family Favorite

Let’s get right to the heart of the matter: the Simple Ground Beef Casserole is a tried-and-true recipe that never disappoints. Whether you’re looking for a meal to satisfy a hungry crew after soccer practice or simply trying to bring the family around the dinner table, this dish fits the bill perfectly. It’s straightforward enough that even novice cooks can whip it up with confidence, yet it boasts dinner-party-worthy flavors. Plus, with basic ingredients that you often already have at home, you’re just a few steps away from a comforting feast that will leave everyone asking for seconds.

Ingredient Breakdown

To ensure you have everything on hand, here’s your shopping list for this delightful casserole:

  • 1 pound uncooked penne: Short and sturdy, perfect for holding onto the saucy goodness.
  • 1 tablespoon olive oil: Adds a touch of richness and helps prevent sticking.
  • 1 pound lean ground beef: For that hearty, meaty base, choose ground sirloin for less fat.
  • 1/2 medium onion, chopped: Provides aromatic depth and a touch of sweetness.
  • 1 clove garlic, minced: Because who can resist the allure of garlic?
  • 1.5 cups marinara sauce: Choose your favorite brand or homemade version for all the flavor.
  • Salt & pepper to taste: Seasoning is key to unlocking every flavor note.
  • 1.5 cups shredded cheddar cheese: The ultimate topping for that gooey, cheesy finish.

Step-by-Step Method

Now let’s get down to the nitty-gritty of making this delectable casserole:

  1. Preheat your oven to 400°F and move the rack to the middle position. This ensures even cooking.
  2. Grease a 9×13 baking dish. A non-stick spray works best, but butter will add flavor.
  3. Boil a large, salted pot of water for the penne. Add the pasta and cook it for 10 minutes; it should be slightly underdone to avoid mushiness later. Don’t forget to stir!
  4. In a skillet, add the olive oil, ground beef, and chopped onion. Sauté over medium-high heat, breaking the meat up as you go, for 10 minutes until browned.
  5. Once the beef is cooked through, stir in the minced garlic and cook for another minute, allowing it to become fragrant.
  6. If there’s excess fat in the skillet, spoon it out carefully. Then stir in the marinara sauce and warm everything through for about two minutes. Taste and season with salt and pepper as needed.
  7. Drain the penne and pour it into the greased baking dish, then pour the beef mixture over the pasta. Toss until everything is combined; you want that sauce evenly distributed.
  8. Top with an even layer of shredded cheddar cheese. For extra cheesiness, you can stir in an additional half cup of cheese before topping.
  9. Bake for 10 minutes, uncovered, until the cheese is melted and bubbling. If you’re feeling adventurous, broil it for a couple of minutes at the end to get that lovely crispy top.
  10. Serve immediately, and watch those plates empty in delight.

Healthy Reasons to Love This

With a serving size ideal for satisfying appetites, this casserole clocks in at approximately 400 calories per serving. It offers a protein punch of 26 grams, along with 35 grams of carbohydrates, 18 grams of fat, and 3 grams of fiber. The combination of beef and cheese provides essential nutrients such as iron, calcium, and B vitamins, making this dish not only delicious but also nutritionally sound. Pair it with a salad for a well-rounded meal!

Perfect Pairings

To really elevate your Simple Ground Beef Casserole experience, serve it alongside a fresh, crisp green salad drizzled with vinaigrette. It cuts through the richness of the casserole and adds a refreshing touch. If it’s a chilly night, a side of garlic bread can be a comforting addition. Don’t forget a light dessert—perhaps some fruit or a sorbet—to cleanse the palate after all that deliciousness!

How to Store It Right

Leftovers? You scored! This casserole stores beautifully. Simply let it cool to room temperature, cover it tightly with foil or plastic wrap, and pop it in the fridge, where it will stay fresh for about 3-4 days. Want to keep it longer? Consider freezing it; it can last up to three months. For the best reheating results, thaw it in the fridge overnight and then pop it back in the oven at 350°F until heated through.

Pro Tips

  1. For added depth of flavor, try using a mixture of beef and Italian sausage—it’s an incredibly tasty twist!
  2. Mixing in some chopped bell peppers or zucchini can give your casserole some added nutrition and color.
  3. Consider using a different cheese topping like mozzarella or a blend of Italian cheeses for a little variety.
  4. If you find your casserole too thick, add a splash of beef broth or a bit of extra marinara to loosen it up.
  5. To make the process even quicker, cook the pasta ahead of time and store it in the refrigerator for an easy, fast assembly at dinner time.

Flavor Twists

  • Seasonal Twist: In the fall, add in some roasted butternut squash cubes for a seasonal touch that pairs beautifully with the beef and cheese.
  • Gourmet Option: Swap out the marinara for a homemade bolognese sauce for that upscale flavor and a bit more texture.
  • Playful Variation: Substitute half of the lean beef with cooked, crumbled chorizo for a spicy kick that will surprise your taste buds!

Learn from My Mistakes

  1. Too much liquid: If your casserole ends up soupy, it might be due to excess sauce or not draining the pasta properly. Always drain well and don’t overdo the sauce.
  2. Overcooking the pasta: If you cook the penne for too long, it can become mushy. Aim for al dente—remember, it’ll continue cooking in the oven!
  3. Lack of seasoning: Don’t skip the seasoning phase! Taste as you go and adjust with salt and pepper for the best flavor.
  4. Uneven cheese melting: If you want that beautiful golden cheese top, spreading it evenly is crucial. Otherwise, you might end up with some spots completely bare.
  5. Skimping on leftovers: If you don’t cover it well, leftovers can dry out in the fridge. Make sure to keep it sealed tight!

Creative Second-Day Ideas

  1. Casserole Frittata: Whisk together eggs, pour them over the leftover casserole in a skillet and cook until set for a unique breakfast!
  2. Stuffed Peppers: Use the leftovers to fill halved bell peppers, top with cheese, and bake until the peppers are tender.
  3. Casserole Soup: Heat up the leftovers in a pot with extra broth and some diced tomatoes for a comforting soup that feels fresh and new.

FAQs

Can I make Simple Ground Beef Casserole in advance?

Absolutely! You can assemble it ahead of time, cover it, and keep it in the fridge for up to 24 hours before baking. Just add a few extra minutes to the baking time if it’s coming straight out of the fridge.

What can I substitute for ground beef?

Ground turkey or chicken works well for a leaner option, or even lentils for a vegetarian twist. Just adjust the cooking time accordingly!

Can I freeze this casserole?

Yes! It freezes well. Make sure to cool it completely before wrapping tightly and storing in the freezer for up to three months. Thaw in the fridge before reheating.

How do I know when my casserole is done?

Look for bubbling cheese and a slightly golden top. A food thermometer can help, aiming for an internal temperature of 165°F for safe consumption.

This Simple Ground Beef Casserole is your new go-to for feeding a crowd or satisfying a family meal. With its bold flavors and comforting texture, it’s bound to become a cherished dish at your table. Happy cooking!

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